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Platelet count and mean volume (MPV) in association with plasma HCO3- in regular hemodialysis patients
Nasri, Hamid;Baradaran, Azar;
Revista Brasileira de Hematologia e Hemoterapia , 2006, DOI: 10.1590/S1516-84842006000200012
Abstract: end-stage renal failure often is associated with abnormal bleeding that may represent an important complication of this disorder. the hemorrhagic tendency currently is attributed to altered primary hemostasis, mainly platelet dysfunction. the aim of the present study was to elucidate whether and how in patients, with uremia on hemodialysis, the level of plasma hco3- affects the mean plt volume (mpv) and count. the total patients were 36 (f=15, m=21). the mean patients' age was 46 (±16) years. the mean length of the time patients had received hemodialysis was 32 (±36) months. the mean plt count was 165 (±70) [x103m/l]. the mean mpv was 9 (±1) fl. the mean plasma hco3- was 20 (±2.6) meq/l. in this study a significant inverse correlation of plt count with mpv and a significant positive association of plt count with plasma hco3 and also a significant inverse correlation of mpv with plasma hco3- were found. positive association of mild relative acidemia with plt count and its negative correlation with mpv may further support the reverse epidemiology of serum bicarbonate in end-stage renal disease patients on hemodialysis which needs more attention as a protective role in mild relative acidosis of regular hemodialysis patients.
Helicobacter Pylori IgG Antibodies in Association with Secondary Hyperparathyroidism in End-stage Renal Failure Patients Undergoing Regular Hemodialysis
Hamid Nasri,Azar Baradaran
Pakistan Journal of Biological Sciences , 2006,
Abstract: The aim of present study was the assessment of relationships between PTH abnormalities and the parameter of Helicobacter pylori (H. pylori) infection as expressed by concentration of IgG antibodies against H. pylori. The study was carried out on 44 (F = 17, M = 27) stable hemodialysis (HD) patients with upper gastrointestinal symptoms. A significant positive correlations of H. pylori IgG antibody titers with serum iPTH and phosphorus also a significant inverse correlation of H. pylori IgG antibody titers with serum alkalin phosphatase was found. It is known that hyperparathyroidism is connected with stimulation of gastrin synthesis as well with increased acidity of gastric juice. Hypergastrinaemia induced stimulation of gastrin synthesis and resultant increased acidity of gastric juice could intensify the H. pylori infection in hemodialysis patients. We strongly propose to more study on the association of secondary hyperparathyroidism with H. pylori infection, because both dyspeptic symptoms and secondary hyperparathyroidism are quite common in chronic hemodialysis patients and in the meantime needs more attention toward control of high levels of parathormone in HD patients.
Association of Serum C-Reactive Protein (CRP) with Some Nutritional Parameters of Maintenance Hemodialysis Patients
Azar Baradaran,Hamid Nasri
Pakistan Journal of Nutrition , 2005,
Abstract: Malnutrition and inflammation are common in hemodialysis patients, and are usually closely associated. Serum C-reactive protein (CRP) concentrations have been found to be significantly elevated in hemodialysis patients and reflects chronic inflammation, and as an acute-phase reactant, is a sensitive and independent marker of malnutrition. To investigate the association of serum CRP level with some nutritional variables in diabetic and non diabetic end-stage renal failure patients undergoing regular hemodialysis, we designed a study of 36 maintenance hemodialysis patients (f = 15 m = 21), consisting of 25 non-diabetic HD patients and 11 diabetic HD patients. In this study we found a near significant difference of CRP between diabetic and non-diabetics of total patients with more values of CRP in diabetics, a significant difference of CRP between diabetic and non-diabetic of female HD patients with more values in diabetics and a significant difference of CRP between males and female of non-diabetic population with more values of CRP in males. An inverse correlation of serum CRP with serum cholesterol and triglyceride levels and a near significant positive correlations of CRP with serum ALP and with serum iPTH were found. An inverse correlation of serum CRP with dialysis efficacy was seen too. No significant association between serum CRP and serum albumin was seen. Compatible with some studies and in contrast to some other studies, the association of serum albumin with serum CRP levels in this study was insignificant. The positive correlation of high serum PTH with inflammation implies further need to control of hyperphosphatemia and secondary hyperparathyroidism in HD patients, also inverse correlation of serum CRP with cholesterol and triglyceride further support the malnutrition-inflammation complex syndrome (MICS) which frequently seen in HD patients.
Helicobacter Pylori IgG Specific Antibodies in Association with Serum Albumin in Maintenance Hemodialysis Patients
Azar Baradaran,Hamid Nasri
Pakistan Journal of Nutrition , 2005,
Abstract: This study was conducted to determine the association of serum albumin of hemodialysis patients with Helicobacter pylori (H. pylori) infection. 124 subjects consisting of 44 (F = 27 M = 17) hemodialysis (HD) patients with 34 (F = 21 M = 13) non diabetic hemodialysis and 10 (F = 4 M = 6) diabetic hemodialysis patients and also 88 patients (F = 50 M = 38 ) were studied. In this study significant inverse correlations of Helicobacter pylori IgG antibodies with serum albumin and with dialysis adequacy were seen. Also near significant inverse correlations of Helicobacter pylori IgG antibodies with dialysis duration and dosage were seen too. The inverse correlation of H. pylori infection with serum albumin may show its important role in malnutrition of hemodialysis which frequently seen in these patients.
INVERSE CORRELATION OF C-REACTIVE PROTEIN WITH ANEMIA IN MAINTENANCE HEMODIALYSIS PATIENTS
Hamid Nasri,Azar Baradaran
Acta Facultatis Medicae Naissensis , 2005,
Abstract: The aim of the paper was to test the association between serum C-reactive protein (CRP) and serum ferritin and its role in the severity of anemia of hemodialysis patients. A cross-sectional study was conducted on the patients with an end-stage renal disease who underwent HD treatment with acetate basis dialysate and polysulfone membranes. There were 36 patients overall (f=15, m=21), 25 of whom were non-diabetic HD patients and 11 diabetic HD patients. There was an approximate significant inverse correlation between serum CRP and hemoglobin level and also a significant positive correlation between serum CRP and serum iron as well as an approximate significant inverse correlation between serum CRP and HD adequacy. A significant positive correlation between serum CRP and serum ferritin was registered. Malnutrition-inflammation complex syndrome may increase serum ferritin concentration apart from iron status, and needs more attention during iron therapy for the treatment of anemia in regular HD patients.
Parathyroid Gland Function in Kidney Transplanted Patient: A single Center Experience
Azar BARADARAN,Hamid NASRI
Applied Medical Informatics , 2012,
Abstract: Introduction: Information on the time course of serum parathormone levels after renal transplantation is scanty. Both the abrupt cessation of calcium-containing phosphorus binders and vitamin D (analogs) at the time of surgery and the recovery of renal function may be hypothesized to affect parathyroid gland. This study firstly examined frequency distribution of various biochemical parameters such as alkaline phosphatase (ALP), phosphorus (P), intact parathormone (iPTH) and calcium (Ca) in renal transplanted patients and secondly examined the relationship between these parameters and various demographic data of renal transplanted recipients. Material and Methods: we studied 72 renal transplanted patients (47 men and 25 women with mean ages of 44 ± 12 years and mean body mass index of 24.2 ± 3.9. Serum Ca, P, ALP and serum iPTH were measured. Results: In this study, mean serum Ca and iPTH were 9.5 ± 0.7mg/dL and18.4 ± 8.2 Pg/mL (median=16.5). Mean serum ALP was 169 ± 133 IU/L (median=131). In this study, there was a negative relationship between serum iPTH and creatinine clearance (r=-0.44 P< 0.001). There was no correlation between the duration of renal transplantation and serum iPTH (P> 0.05). There were inverse correlations of serum ALP with age (r=-0.35 P= 0.02) and duration of kidney transplantation (r=-0.29 P= 0.01). Conclusions: In contrast to previous findings, in this group of patients, there was not secondary hyperparathyroism or significantly increased bone activity. The results showed suppressed parathormone secretion. The reason may be due to excessive intake of calcium and Vitamin D analogues, which suppress the parathyroid gland, and may prone these patients to adynamic bone disease.
Original paper Helicobacter pylori IgG antibodies in association with secondary hyperparathyroidism in end-stage renal failure patients undergoing regular hemodialysis
Azar Baradaran,Hamid Nasri
Archives of Medical Science , 2005,
Abstract: Helicobacter pylori (H. pylori) has been shown to play an important role in the development of gastritis and gastric ulcer. Excess parathyroid hormone (PTH) has long been considered detrimental to the health of patients with end-stage renal disease. PTH has been implicated as a multisystem uremic toxin, and hyperparathyroidism can be a debilitating complication in dialyzed patients. The aim of our study was the assessment of relationships between PTH abnormalities and concentration of IgG antibodies against H. pylori. The study included 44 (F=17, M=27) stable hemodialysis (HD) patients with upper gastrointestinal symptoms. Significant positive correlations between H. pylori IgG antibody titers with serum iPTH and phosphorus and significant inverse correlation of H. Pylori IgG antibody titers with serum alkalin phosphatase were found. Hyperparathyroidism is related with stimulation of gastrin synthesis as well with increased acidity of gastric juice. Hypergastrinaemia induced stimulation of gastrin synthesis and resultant increased acidity of gastric juice could intensify the H. pylori infection in HD patients. Further studies on the association of secondary hyperparathyroidism with helicobacter pylori infection are necessary, because both dyspeptic symptoms and secondary hyperparathyroidism are quite common in HD patients and in the meantime, more attention toward control of high levels of parathormone in HD patients is needed.
ORIGINAL PAPER: The association of 25-hydroxyvitamin D levels with secondary hyperparathyroidism in end-stage renal failure patients undergoing regular hemodialysis
Hamid Nasri,Azar Baradaran
Archives of Medical Science , 2005,
Abstract: Introduction: To investigate the role of 25-OHD as a marker of nutrition and its association with mineral metabolism and serum parathormone secretion in end-stage renal failure patients undergoing regular hemodialysis (HD), a cross sectional study was carried out on a group of maintenance hemodialysis patients. Material and methods: Serum 25-hydroxy (25-OH vitamin D) levels, Intact serum PTH (iPTH) and also serum C-reactive protein(CRP), calcium, phosphorus and alkaline phosphatase (ALP) were measured. Results: In the study, significant differences of serum 25-OH vitamin D between diabetic and non-diabetics of male dialysis patients with more values in nondiabetic HD patients and a significant positive correlation of serum 25-OH vitamin D with BMI and also a near significant inverse correlation of serum 25-OH vitamin D with serum phosphorus were found, also a significant inverse correlation of serum 25-OH VitD with serum calcium was seen, too. Moreover, a weakly significant inverse correlation of serum 25-OH vitamin D with serum iPTH was seen, too. In this study no significant association between serum 25-OH vitamin D with serum albumin, CRP, ALP, dialysis adequacy and ages of the patients, duration and sessions of dialysis were found. Conclusions: In hemodialysis patients, low serum 25-OHD levels could be a risk factor for secondary hyperparathyroidism. Serum 25-OHD could show the nutritional status of HD patients. In dialysis patients, we suggest that the plasma levels of 25-OHD are maintained around the upper limit of the reference range of sunny countries.
Correlation of Serum Magnesium with Serum Parathormone Levels in Patients on Regular Hemodialysis
Baradaran Azar,Nasri Hamid
Saudi Journal of Kidney Diseases and Transplantation , 2006,
Abstract: Secondary hyperparathyroidism (SHPT) is a common, important, and treatable complication of end-stage renal disease. This study was conducted to investigate the role of serum magnesium (Mg) in regulating the secretion of parathyroid hormone (PTH) by the parathyroid gland in patients on maintenance hemodialysis (HD). Pre-dialysis serum levels of calcium (Ca), phosphorus (P), Mg, alkaline phosphatase (ALP), intact serum PTH (iPTH), serum 25-hydroxy Vitamin D (25-OH Vit D) and plasma bicarbonate (HCO3) were measured. The Urea Reduction Rate as well as duration and dosage of HD treatment were noted. Our study did not show any significant correlation between serum Mg levels and duration of HD treatment, levels of serum ALP, and plasma HCO3, Ca and P. An inverse correlation, albeit insignificant, was found between the serum Mg levels and iPTH (r=-0.30 p=0.079); also, a significant positive correlation was found between serum Mg levels and serum 25-OH Vit D levels (r= 0.40 p= 0.009). Our findings are in agreement with previous data, which suggest that factors other than serum Mg are more important in the regulation of PTH secretion in HD patients. A positive and strong association between serum Mg with 25-OH Vit D needs to be studied in greater detail.
Helicobacter pylori specific IgG antibody and serum magnesium in type-2 diabetes mellitus chronic kidney disease patients
Baradaran Azar,Nasri Hamid
Saudi Journal of Kidney Diseases and Transplantation , 2011,
Abstract: Infection with Helicobacter pylori (H. pylori) is common in diabetics with inade-quately controlled blood sugar. Evidence has been published suggesting that the prevalence of H. pylori infection is higher in patients with type-2 diabetes mellitus (T2DM) as opposed to the normal population. This study was conducted to investigate the association between serum magnesium (Mg) levels and H. pylori infection in T2DM patients with various glomerular function rates (GFRs). A total of 94 patients with mean age of 62 (±12) years and the duration of diabetes of 7.9 (±6.9) years (median: 7 years), were studied. The mean HbA1c in the study patients was 7.8 (±1.9) g/dL. The mean serum Mg was 2 (±0.50) mg/dL (median: 2 mg/dL), and the mean creatinine clea-rance was 62 (±23) mL/min (median: 64 mL/min). The mean value of serum H. pylori specific IgG antibody titers in the study patients was 3.9 ± 4 U/mL (median 1.9 U/mL). No significant relation-ship was found between the serum H. pylori specific IgG antibody titers and serum Mg levels and the age of the patients, creatinine clearance and duration of diabetes mellitus (DM). We could not find any significant positive association between serum Mg and H. pylori infection even among patients who had GFR below 40 mL/min. In a previous study on a group of patients on hemo-dialysis (HD), we had found a positive correlation between serum Mg and H. pylori infection. Thus, the high serum Mg level as well as its higher concentration in the gastric mucosa might facilitate the colonization of H. pylori in the stomach of patients on HD, but not in patients with various stages of renal failure that were not on HD.
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